Journal article

Towards Improving Point-of-Care Diagnosis of Non-malaria Febrile Illness: A Metabolomics Approach

Saskia Decuypere, Jessica Maltha, Stijn Deborggraeve, Nicholas JW Rattray, Guiraud Issa, Kabore Berenger, Palpouguini Lompo, Marc C Tahita, Thusitha Ruspasinghe, Malcolm McConville, Royston Goodacre, Halidou Tinto, Jan Jacobs, Jonathan R Carapetis



INTRODUCTION: Non-malaria febrile illnesses such as bacterial bloodstream infections (BSI) are a leading cause of disease and mortality in the tropics. However, there are no reliable, simple diagnostic tests for identifying BSI or other severe non-malaria febrile illnesses. We hypothesized that different infectious agents responsible for severe febrile illness would impact on the host metabolome in different ways, and investigated the potential of plasma metabolites for diagnosis of non-malaria febrile illness. METHODOLOGY: We conducted a comprehensive mass-spectrometry based metabolomics analysis of the plasma of 61 children with severe febrile illness from a malaria-endemic rural African s..

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Funding Acknowledgements

This work was supported by a Telethon Kids Institute small grant & a Merit Award of the Department of Health Western Australia to SDec, JRC, MM and TR; the Institute of Tropical Medicine Belgium to JM, JJ, GI, KB, PL, MCT and HT; the UK Medical Research Council to NJWR and RG; and the Flemish Ministry of Sciences (EWI, SOFI grant) to SDeb and JJ. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.