Journal article
Endurance training in early life results in long-term programming of heart mass in rats
Glenn D Wadley, Rhianna C Laker, Glenn K McConell, Mary E Wlodek
PHYSIOLOGICAL REPORTS | WILEY | Published : 2016
DOI: 10.14814/phy2.12720
Abstract
Being born small for gestational age increases the risk of developing adult cardiovascular and metabolic diseases. This study aimed to examine if early-life exercise could increase heart mass in the adult hearts from growth restricted rats. Bilateral uterine vessel ligation to induce uteroplacental insufficiency and fetal growth restriction in the offspring (Restricted) or sham surgery (Control) was performed on day 18 of gestation in WKY rats. A separate group of sham litters had litter size reduced to five pups at birth (Reduced litter), which restricted postnatal growth. Male offspring remained sedentary or underwent treadmill running from 5 to 9 weeks (early exercise) or 20 to 24 weeks o..
View full abstractGrants
Awarded by Medical Research Council