Maternal alcohol intake around the time of conception causes glucose intolerance and insulin insensitivity in rat offspring, which is exacerbated by a postnatal high-fat diet
Emelie M Gardebjer, Stephen T Anderson, Marie Pantaleon, Mary E Wlodek, Karen M Moritz
FASEB JOURNAL | WILEY | Published : 2015
Alcohol consumption throughout pregnancy can cause metabolic dysregulation, including glucose intolerance in progeny. This study determined if periconceptional (PC) alcohol (12% v/v in a liquid diet) (PC:EtOH) consumed exclusively around conception results in similar outcomes in Sprague-Dawley rats. Control (C) rats were given a liquid diet containing no alcohol but matched to ensure equal caloric intake. PC maternal alcohol intake (from 4 days before conception until day 4 of gestation), resulted in offspring with elevated fasting plasma glucose (∼10-25%, P < 0.05), impaired glucose tolerance (P < 0.05), and decreased insulin sensitivity (P < 0.01) at 6 months of age. This was associated wi..View full abstract
Awarded by National Health and Medical Research Council of Australia
The authors acknowledge the funding provided by the National Health and Medical Research Council of Australia (1046137), and thank Kerri Tyrell, School of Biomedical Sciences, The University of Queensland, for expert assistance with the insulin assay.