Journal article

Evaluation of point-of-care test for elevated tear matrix metalloproteinase 9 in post-LASIK dry eyes

Tommy CY Chan, Cong Ye, Kwok Ping Chan, Kai On Chu, Vishal Jhanji

BRITISH JOURNAL OF OPHTHALMOLOGY | BMJ PUBLISHING GROUP | Published : 2016

Abstract

AIM: To evaluate the performance of a point-of-care test for detection of matrix metalloproteinase 9 (MMP-9) levels in post-laser-assisted in situ keratomileusis (LASIK) dry eyes. METHODS: A comparative study between patients with mild to moderate post-LASIK dry eyes and age-matched normal subjects was conducted. Ocular surface disease index (OSDI), tear break-up time (TBUT), and tear film MMP-9 and total protein levels were compared between the two groups. A point-of-care test device (RPS InflammaDry, Sarasota, Florida, USA) was utilised to confirm elevated MMP-9 levels in tear film. RESULTS: Fourteen post-LASIK dry eyes and 34 normal eyes were included. There was no significant difference ..

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