Journal article
Intratracheal atomized surfactant provides similar outcomes as bolus surfactant in preterm lambs with respiratory distress syndrome
I Milesi, DG Tingay, E Zannin, F Bianco, P Tagliabue, F Mosca, A Lavizzari, ML Ventura, CE Zonneveld, EJ Perkins, D Black, M Sourial, RL Dellacá
Pediatric Research | Published : 2016
DOI: 10.1038/pr.2016.39
Abstract
Background:Aerosolization of exogenous surfactant remains a challenge. This study is aimed to evaluate the efficacy of atomized poractant alfa (Curosurf) administered with a novel atomizer in preterm lambs with respiratory distress syndrome.Methods:Twenty anaesthetized lambs, 127 ± 1 d gestational age, (mean ± SD) were instrumented before birth and randomized to receive either (i) positive pressure ventilation without surfactant (Control group), (ii) 200 mg/kg of bolus instilled surfactant (Bolus group) at 10 min of life or (iii) 200 mg/kg of atomized surfactant (Atomizer group) over 60 min from 10 min of life. All lambs were ventilated for 180 min with a standardized protocol. Lung mechanic..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
D.G.T. is supported by a National Health and Medical Research Council Clinical Career Development Fellowship (Grant ID 1053889), Canberra, Australia. D.G.T., E.R, D.B., C.E.Z. and M.S. are supported by the Victorian Government Operational Infrastructure Support Program, Melbourne, Australia.