Towards identification of immune and genetic correlates of severe influenza disease in Indigenous Australians

EB Clemens; EJ Grant; Z Wang; S Gras; P Tipping; J Rossjohn; A Miller; SYC Tong; K Kedzierska

Journal article

Towards identification of immune and genetic correlates of severe influenza disease in Indigenous Australians

EB Clemens, EJ Grant, Z Wang, S Gras, P Tipping, J Rossjohn, A Miller, SYC Tong, K Kedzierska

Immunology and Cell Biology | Published : 2016

DOI: 10.1038/icb.2015.93

Download PDF

Abstract

Indigenous populations, including Indigenous Australians, are highly susceptible to severe influenza disease and the underlying mechanisms are unknown. We studied immune and genetic factors that could predicate severe influenza disease in Indigenous Australians enrolled in the LIFT study: looking into influenza T-cell immunity. To examine CD8+ T-cell immunity, we characterised human leukocyte antigen (HLA) profiles. HLA typing confirmed previous studies showing predominant usage of HLA-A∗02:01, 11:01, 24:02, 34:01 and HLA-B∗13:01, 15:21, 40:01/02, 56:01/02 in Indigenous Australians. We identified two new HLA alleles (HLA-A∗02:new and HLA-B∗56:new). Modelling suggests that variations within H..

View full abstract

University of Melbourne Researchers

Bridie Clemens Author

Jamie Rossjohn Author

Steven Tong Author

Katherine Kedzierska Author

Related Projects (4)

LIMITING THE IMPACT OF INFLUENZA

The development of better ways to prevent and treat influenza infection will be a major step forward in lessening the impact of the virus in..

Understanding influenza-specific T cell immunity in the Indigenous population

Hospitalisation and death rates from influenza are high in the Indigenous population. There is an urgent need for one-shot universal vaccine..

T CELL IMMUNITY AGAINT SESONAL AND PANDEMIC INFLUENZA VIRUSES

Introduction of a new influenza strain into human circulation leads to a rapid global spread of the virus (e.g. H1N1 2009 pandemic) due to m..

CLINICAL AND GENOMIC ASPECTS OF STAPHYLOCOCCUS AUREUS AND OTHER INFECTIOUS DISEASES IN NORTHERN AUSTRALIA

The burden of infectious disease is high in Indigenous populations in northern Australia and patterns of disease differ. My research propose..

Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

We thank Loyla Lesley for recruitment of Indigenous Australian donors and ImmunoID facility for FACS sorting. This work was supported by Australian National Health and Medical Research Council (NHMRC) Project Grants to KK, ST and AM (AI1042662), and an NHMRC Program Grant (AI1071916) to KK. KK is an NHMRC Career Development Fellow (CDF) 2 (1023294), SYCT in an NHMRC CDF1 (1065736), EBC is an NHMRC Peter Doherty Fellow. SG is an ARC Future Fellow (FT120100416) and JR is an NHMRC Australia Fellow (AF50). EJG is a recipient of an NHMRC Aboriginal and Torres Strait Islander Health Research Scholarship and Douglas and Lola Scholarship in Medical Science.