BRAF inhibition in BRAFV600E-positive anaplastic thyroid carcinoma

Abstract

The efficacy of targeted monotherapy for BRAFV600E-positive anaplastic thyroid carcinomas (ATC) is not established. We report 2 cases of BRAFV600E-positive ATC treated with a BRAF inhibitor. A 49-year-old woman with a T4bN1bM0 ATC manifested symptomatic metastatic disease 8 weeks after radical chemoradiotherapy. Within 1 month of BRAF inhibitor monotherapy, a complete symptomatic response was observed, with FDG-PET scan confirming metabolic and radiologic response. Treatment was terminated after 3 months because of disease progression. The patient died 11 months after primary diagnosis. A 67-year-old man received first-line BRAF inhibitor for a T4aN1bM0 ATC. Within 10 days of treatment his p..