Emerging Insights into the Roles of Membrane Tethers from Analysis of Whole Organisms: The Tip of an Iceberg?
Wei Hong Toh, Paul A Gleeson
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | FRONTIERS MEDIA SA | Published : 2016
Membrane tethers have been identified throughout different compartments of the endomembrane system. It is now well established that a number of membrane tethers mediate docking of membrane carriers in anterograde and retrograde transport and in regulating the organization of membrane compartments. Much of our information on membrane tethers have been obtained from the analysis of individual membrane tethers in cultured cells. In the future it will be important to better appreciate the network of interactions mediated by tethers and the potential co-ordination of their collective functions in vivo. There are now a number of studies which have analyzed membrane tethers in tissues and organisms..View full abstract
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Awarded by National Health and Medical Research Council of Australia
Awarded by Australian Research Council
This work was supported by funding from the National Health and Medical Research Council of Australia (PG1082600) and the Australian Research Council (DP130103207).