Cyclosporin A significantly improves preeclampsia signs and suppresses inflammation in a rat model

Abstract

Preeclampsia is associated with an increased inflammatory response. Immune suppression might be an effective treatment. The aim of this study was to examine whether Cyclosporin A (CsA), an immunosuppressant, improves clinical characteristics of preeclampsia and suppresses inflammation in a lipopolysaccharide (LPS) induced preeclampsia rat model. Pregnant rats were randomly divided into 4 groups: group 1 (PE) rats each received LPS via tail vein on gestational day (GD) 14; group 2 (PE + CsA5) rats were pretreated with LPS (1.0 μg/kg) on GD 14 and were then treated with CsA (5 mg/kg, ip) on GDs 16, 17 and 18; group 3 (PE + CsA10) rats were pretreated with LPS (1.0 μg/kg) on GD 14 and were then..