Cyclosporin A significantly improves preeclampsia signs and suppresses inflammation in a rat model
Bihui Hu, Jinying Yang, Qian Huang, Junjie Bao, Shaun Patrick Brennecke, Huishu Liu
CYTOKINE | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2016
Preeclampsia is associated with an increased inflammatory response. Immune suppression might be an effective treatment. The aim of this study was to examine whether Cyclosporin A (CsA), an immunosuppressant, improves clinical characteristics of preeclampsia and suppresses inflammation in a lipopolysaccharide (LPS) induced preeclampsia rat model. Pregnant rats were randomly divided into 4 groups: group 1 (PE) rats each received LPS via tail vein on gestational day (GD) 14; group 2 (PE+CsA5) rats were pretreated with LPS (1.0 μg/kg) on GD 14 and were then treated with CsA (5mg/kg, ip) on GDs 16, 17 and 18; group 3 (PE+CsA10) rats were pretreated with LPS (1.0 μg/kg) on GD 14 and were then trea..View full abstract
Awarded by National Natural Sciences Foundation of China
The authors thank Lijun Dai, Chengjie Liang in Guangzhou Medical University for the help with the animal experiments. This study was supported by Grants from the National Natural Sciences Foundation of China (81170594, 30471828, and 30973206).