Journal article

Are obesity and body fat distribution associated with low back pain in women? A population-based study of 1128 Spanish twins

Amabile B Dario, Manuela L Ferreira, Kathryn Refshauge, Juan F Sanchez-Romera, Alejandro Luque-Suarez, John L Hopper, Juan R Ordonana, Paulo H Ferreira



PURPOSE: To investigate the relationship between different measures of obesity and chronic low back pain (LBP) using a within-pair twin case-control design that adjusts for genetics and early shared environment. METHODS: A cross-sectional association between lifetime prevalence of chronic LBP and different measures of obesity (body mass index-BMI; percent body fat; waist circumference; waist-hip ratio) was investigated in 1128 female twins in three stages: (i) total sample analysis; (ii) within-pair case-control analysis for monozygotic (MZ) and dizygotic (DZ) twins together; (iii) within-pair case-control analysis separated by DZ and MZ. Odds ratios (OR) and 95% confidence intervals (CI) we..

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Awarded by Regional Agency for Science and Technology, Murcia, Spain

Awarded by Ministry of Science and Innovation, Spain

Funding Acknowledgements

The authors would like to acknowledge the participation of the twins and the assistance of staffs and researchers from the Murcia Twin Registry for the implementation of this study. We also acknowledge the financial support to the Murcia Twin Registry by the Fundacion Seneca, Regional Agency for Science and Technology, Murcia, Spain (08633/PHCS/08 and 15302/PHCS/10) and Ministry of Science and Innovation, Spain (PSI11560-2009). Funding for this project has been also received from Fundacion MAPFRE (2012). MLF is a Sydney Medical Foundation Fellow. ABD is supported by the National Council for Scientific and Technological Development (CNPq) program "Science without Borders''-Brazil.