Journal article
Meta-analysis of radical resection rates and margin assessment in pancreatic cancer
MD Chandrasegaram, D Goldstein, J Simes, V Gebski, JG Kench, AJ Gill, JS Samra, ND Merrett, AJ Richardson, AP Barbour, J Fawcett, PS Grimison, C Christophi, R Padbury, KS Haghighi, JW Chen, M Nikfarjam, N O'Rourke, N Spry
British Journal of Surgery | OXFORD UNIV PRESS | Published : 2015
DOI: 10.1002/bjs.9892
Abstract
Background R0 resection rates (complete tumour removal with negative resection margins) in pancreatic cancer are 70-80 per cent when a 0-mm margin is used, declining to 15-24 per cent with a 1-mm margin. This review evaluated the R0 resection rates according to different margin definitions and techniques. Methods Three databases (MEDLINE from 1946, PubMed from 1946 and Embase from 1949) were searched to mid-October 2014. The search terms included 'pancreatectomy OR pancreaticoduodenectomy' and 'margin'. A meta-analysis was performed with studies in three groups: group 1, axial slicing technique (minimum 1-mm margin); group 2, other slicing techniques (minimum 1-mm margin); and group 3, studi..
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Funding Acknowledgements
The authors acknowledge grant support from Cancer Australia and Cancer Institute New South Wales for M.D.C. and the statistical analyses respectively.