Journal article
Acquisition and Longevity of Antibodies to Plasmodium vivax Preerythrocytic Antigens in Western Thailand
RJ Longley, A Reyes-Sandoval, E Montoya-Díaz, S Dunachie, C Kumpitak, W Nguitragool, I Mueller, J Sattabongkot
Clinical and Vaccine Immunology | Published : 2016
DOI: 10.1128/CVI.00501-15
Abstract
Plasmodium vivax is now the dominant Plasmodium species causing malaria in Thailand, yet little is known about naturally acquired immune responses to this parasite in this low-transmission region. The preerythrocytic stage of the P. vivax life cycle is considered an excellent target for a malaria vaccine, and in this study, we assessed the stability of the seropositivity and the magnitude of IgG responses to three different preerythrocytic P. vivax proteins in two groups of adults from a region of western Thailand where malaria is endemic. These individuals were enrolled in a yearlong cohort study, which comprised one group that remained P. vivax free (by quantitative PCR [qPCR] detection, n..
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Awarded by National Institute of Allergy and Infectious Diseases
Funding Acknowledgements
This work was supported by the National Institute of Allergy and Infectious Diseases (NIH grant 5R01 AI 104822 to J.S.) and the Foundation for Innovative New Diagnostics (to I.M.). Funding was also provided by a Wellcome Trust Career Development Fellowship award, grant 097395, to A.R.-S. The field study was funded by the Bill and Melinda Gates Foundation. I.M. is supported by an NHMRC Senior Research Fellowship (1043345). A.R.-S. is a Jenner Investigator and Oxford Martin School Fellow. S.D. is a Wellcome Trust Intermediate Clinical Fellow. W.N. is a Wellcome Trust Intermediate Fellow in Public Health and Tropical Medicine. The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.