Journal article

Emergence of a novel equine-like G3P[8] inter-genogroup reassortant rotavirus strain associated with gastroenteritis in Australian children

Daniel Cowley, Celeste M Donato, Susie Roczo-Farkas, Carl D Kirkwood



During 2013, a novel equine-like G3P[8] rotavirus emerged as the dominant strain in Australian children with severe rotavirus gastroenteritis. Full genome analysis demonstrated that the strain was an inter-genogroup reassortant, containing an equine-like G3 VP7, a P[8] VP4 and a genogroup 2 backbone I2-R2-C2-M2-A2-N2-T2-E2-H2. The genome constellation of the equine-like G3P[8] was distinct to Australian and global G3P[8] strains. Phylogenetic analysis demonstrated a genetic relationship to multiple gene segments of Japanese strains RVA/JPN/S13-30/2013/G3P[4] and RVA/Human-wt/JPN/HC12016/2012/G1P[8]. The Australian equine-like G3P[8] strain displayed a distinct VP7 antigenic profile when comp..

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Awarded by National Health and Medical Research Council of Australia

Funding Acknowledgements

This work was supported in part by a grant from the National Health and Medical Research Council of Australia (1031473). This research was supported by the Victorian Government's Operational Infrastructure Support Program. C. D. K. is Director of Australian Rotavirus Surveillance Program, which is supported by research grants from vaccine manufacturers CSL and GSK, as well as the Australian Commonwealth Department of Health. C. D. K. is a co-developer of an investigational rotavirus vaccine.