Journal article

Novel Genetic Loci Associated With Retinal Microvascular Diameter

Richard A Jensen, Xueling Sim, Albert Vernon Smith, Xiaohui Li, Johanna Jakobsdottir, Ching-Yu Cheng, Jennifer A Brody, Mary Frances Cotch, Barbara Mcknight, Ronald Klein, Jie Jin Wang, Annette Kifley, Tamara B Harris, Lenore J Launer, Kent D Taylor, Barbara EK Klein, Leslie J Raffel, Xiang Li, M Arfan Ikram, Caroline C Klaver Show all

Circulation: Cardiovascular Genetics | LIPPINCOTT WILLIAMS & WILKINS | Published : 2016

Grants

Awarded by National Institutes of Health (NIH) through the Intramural Research Program of the National Institute of Aging


Awarded by National Eye Institute (NEI)


Awarded by NIH


Awarded by National Heart, Lung, and Blood Institute (NHLBI)


Awarded by National Human Genome Research Institute


Awarded by US Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium through the National Institutes of Health American Recovery and Reinvestment Act


Awarded by NHLBI


Awarded by National Institute on Aging


Awarded by National Center for Advancing Translational Sciences, CTSI


Awarded by National Institute of Diabetes and Digestive and Kidney Disease Diabetes Research Center (DRC) grant


Awarded by MESA


Awarded by National Center for Research Resources


Awarded by National Center for Advancing Translational Sciences, CTSI grant


Awarded by National Institute of Diabetes and Digestive and Kidney Disease Diabetes Research Center (DRC)


Awarded by National Medical Research Council (NMRC), Singapore


Awarded by Biomedical Research Council, Singapore


Awarded by NMRC


Awarded by Australian National Health and Medical Research Council, Canberra Australia


Awarded by Netherlands Genomics Initiative/Netherlands Organisation for Scientific Research (NWO)


Awarded by Netherlands Organization for Scientific Research (NWO)


Awarded by Rainbow Project of the Biobanking and Biomolecular Research Infrastructure Netherlands



Funding Acknowledgements

The Age, Gene, Environment, Susceptibility Study-Reykjavik (AGES): this research was supported by the National Institutes of Health (NIH) through the Intramural Research Program of the National Institute of Aging (ZIAAG007380) and the National Eye Institute (NEI; ZIAEY00401), NIH contract number N01-AG-1-2100, Hjartavernd (the Icelandic Heart Association), the Althingi (Icelandic Parliament), and the University of Iceland Research Fund. We are indebted to Icelandic Heart Association clinic staff and to the AGES participants whose decision to volunteer made this study possible. The funders had no role in data collection, management, analysis and interpretation of the data, preparation, writing and approval of the article, or decision to submit the article for publication. The Atherosclerosis Risk in Communities (ARIC): the study is carried out as a collaborative study supported by National Heart, Lung, and Blood Institute (NHLBI) contracts (HHSN268201100005C, HHSN268201100006C, HHSN268201100007C, HHSN268201100008C, HHSN268201100009C, HHSN268201100010C, HHSN268201100011C, and HHSN268201100012C), R01HL087641, R01HL59367, and R01HL086694; National Human Genome Research Institute contract U01HG004402; and NIH contract HHSN268200625226C. Support for the exome chip genotyping and joint calling was provided by Building on genome-wide association studies for NHLBI diseases: the US Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium through the National Institutes of Health American Recovery and Reinvestment Act of 2009 (5RC2HL102419; principla investigator: E. Boerwinkle). We thank the staff and participants of the ARIC study for their important contributions. The Cardiovascular Health Study (CHS): this research was supported by NHLBI contracts HHSN268201200036C, HHSN268200800007C, N01HC55222, N01HC75150, N01HC85079, N01HC85080, N01HC85081, N01HC85082, N01HC85083, N01HC85086; and NHLBI grants U01HL080295, HL080295, HL087652, HL103612, HL120393, HL105756, and HL068986 with additional contribution from the National Institute of Neurological Disorders and Stroke. Additional support was provided through AG023629 from the National Institute on Aging. A full list of CHS investigators and institutions can be found at http://www.chs-nhlbi.org/pi.htm. The provision of genotyping data was supported in part by the National Center for Advancing Translational Sciences, CTSI grant UL1TR000124, and the National Institute of Diabetes and Digestive and Kidney Disease Diabetes Research Center (DRC) grant DK063491 to the Southern California Diabetes Endocrinology Research Center. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. Multi-Ethnic Study of Atherosclerosis (MESA)-MESA family, MESA SHARe, CTSI, DRC: this research was supported by the MESA contracts N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168, and N01-HC-95169, by grant HL071205 and by UL1-DR-001079 from National Center for Research Resources. Funding for MESA SHARe genotyping was provided by NHLBI contract N02-HL-6-4278. The provision of genotyping data was supported in part by the National Center for Advancing Translational Sciences, CTSI grant UL1TR000124, and the National Institute of Diabetes and Digestive and Kidney Disease Diabetes Research Center (DRC) grant DK063491 to the Southern California Diabetes Endocrinology Research Center.The authors thank the participants of the MESA study, the Coordinating Center, MESA investigators, and study staff for their valuable contributions. A full list of participating MESA investigators and institutions can be found at http://www.mesa-nhlbi.org. Singapore Chinese Eye Study (SCES), Singapore Malay Eye Study (SINDI), and Singapore Indian Eye Study (SiMES): the SCES, SiMES, and SINDI were supported by the National Medical Research Council (NMRC), Singapore (grants 0796/2003, IRG07nov013, IRG09nov014, NMRC 1176/2008, STaR/0003/2008, and CG/SERI/2010), and Biomedical Research Council, Singapore (08/1/35/19/550 and 09/1/35/19/616). C.-Y. Cheng was supported by an award from NMRC (CSA/033/2012). The Singapore Tissue Network and the Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore provided services for tissue archival and genotyping, respectively. The Blue Mountains Eye Study (BMES): the study has been supported by the Australian National Health and Medical Research Council, Canberra Australia (grant numbers: 974159, 211069, 457349, 512423, 475604, and 529912, and the funding for Centre for Clinical Research Excellence in Translational Clinical Research in Eye Diseases, CCRE in TCR-Eye). The cost of genotyping was funded by the NEI/NIH as part of the International AMD Genomics Consortium (IAMDGC), an international collaborative effort to investigate genetics of age-related macular degeneration. Genotyping was performed at the Center for Inherited Diseases Research at the Johns Hopkins University, United States. We also acknowledge the funding body National Institutes of Health Research Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital, and UCL Institute of Ophthalmology, London, United Kingdom. The generation and management of the Illumina exome chip version 1.0 array data for the Rotterdam Study (RS-I) were executed by the Human Genotyping Facility of the Genetic Laboratory of the Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands. The exome chip array data set was funded by the Genetic Laboratory of the Department of Internal Medicine, Erasmus MC, from the Netherlands Genomics Initiative/Netherlands Organisation for Scientific Research (NWO)-sponsored Netherlands Consortium for Healthy Aging (project no. 050-060-810); the Netherlands Organization for Scientific Research (NWO; project number 184021007) and by the Rainbow Project (RP10; Netherlands Exome Chip Project) of the Biobanking and Biomolecular Research Infrastructure Netherlands (http://www.bbmri.nl). We thank Mila Jhamai, Sarah Higgins, and Marijn Verkerk for their help in creating the exome chip database and Carolina Medina-Gomez, MSc, Lennard Karsten, MSc, and Linda Broer, PhD for quality control and variant calling. Variants were called using the best practice protocol developed by Grove et al as part of the CHARGE Consortium exome chip central calling effort.