Journal article
Common and Low Frequency Variants in MERTK Are Independently Associated with Multiple Sclerosis Susceptibility with Discordant Association Dependent upon HLA-DRB1*15:01 Status
MD Binder, AD Fox, D Merlo, LJ Johnson, L Giuffrida, SE Calvert, R Akkermann, GZM Ma, AA Perera, MM Gresle, L Laverick, G Foo, MJ Fabis-Pedrini, T Spelman, MA Jordan, AG Baxter, S Foote, H Butzkueven, TJ Kilpatrick, J Field Show all
Plos Genetics | PUBLIC LIBRARY SCIENCE | Published : 2016
Abstract
Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. The risk of developing MS is strongly influenced by genetic predisposition, and over 100 loci have been established as associated with susceptibility. However, the biologically relevant variants underlying disease risk have not been defined for the vast majority of these loci, limiting the power of these genetic studies to define new avenues of research for the development of MS therapeutics. It is therefore crucial that candidate MS susceptibility loci are carefully investigated to identify the biological mechanism linking genetic polymorphism at a given gene to the increased chance of dev..
View full abstractRelated Projects (1)
Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was supported by the National Multiple Sclerosis Society (US) Grant Number 6007629 to MDB, TJK, JF, HB and ADF; by the Multiple Sclerosis Research Australia Grant Number 13-013 to MDB, JF and TJK; by the National Health and Medical Research Council Grant Number APP1032486 to HB, JF and AGB, and by the Australian Research Council Linkage Grant Number LP110100473 to HB, JF abd AGB. The Florey Institute of Neuroscience and Mental Health acknowledges the strong support from the Victorian Government and in particular the funding from the Operational Infrastructure Support Grant. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.