Journal article

NKG2A complexed with CD94 defines a novel inhibitory natural killer cell receptor

AG Brooks, PE Posch, CJ Scorzelli, F Borrego, JE Coligan

Journal of Experimental Medicine | ROCKEFELLER UNIV PRESS | Published : 1997


CD94 is a C-type lectin expressed by natural killer (NK) cells and a subset of T cells. Blocking studies using anti-CD94 mAbs have suggested that it is a receptor for human leukocyte antigen class I molecules. CD94 has recently been shown to be a 26-kD protein covalently associated with an unidentified 43-kD protein(s). This report shows that NKG2A, a 43-kD protein, is covalently associated with CD94 on the surface of NK cells. Cell surface expression of NKG2A is dependent on the association with CD94 as glycosylation patterns characteristic of mature proteins are found only in NKG2A that is associated with CD94. Analysis of NK cell clones showed that NKG2A was expressed in all NK cell clone..

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University of Melbourne Researchers