Effect of dexmedetomidine added to standard care on ventilator-free time in patients with agitated delirium a randomized clinical trial

MC Reade; GM Eastwood; R Bellomo; M Bailey; A Bersten; B Cheung; A Davies; A Delaney; A Ghosh; F Van Haren; N Harley; D Knight; S McGuiness; J Mulder; S O'Donoghue; N Simpson; P Young

Journal article

Effect of dexmedetomidine added to standard care on ventilator-free time in patients with agitated delirium a randomized clinical trial

MC Reade, GM Eastwood, R Bellomo, M Bailey, A Bersten, B Cheung, A Davies, A Delaney, A Ghosh, F Van Haren, N Harley, D Knight, S McGuiness, J Mulder, S O'Donoghue, N Simpson, P Young

JAMA Journal of the American Medical Association | AMER MEDICAL ASSOC | Published : 2016

DOI: 10.1001/jama.2016.2707

Abstract

IMPORTANCE: Effective therapy has not been established for patients with agitated delirium receiving mechanical ventilation. OBJECTIVE: To determine the effectiveness of dexmedetomidine when added to standard care in patients with agitated delirium receiving mechanical ventilation. DESIGN, SETTING, AND PARTICIPANTS: The Dexmedetomidine to Lessen ICU Agitation (DahLIA) study was a double-blind, placebo-controlled, parallel-group randomized clinical trial involving 74 adult patients in whom extubation was considered inappropriate because of the severity of agitation and delirium. The study was conducted at 15 intensive care units in Australia and New Zealand from May 2011 until December 2013. ..

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University of Melbourne Researchers

Michael Reade Author

Glenn Eastwood Author

Grants

Funding Acknowledgements

This study was partly funded by Hospira Australia through an unrestricted grant of A$25000 plus free study drug supply. Individual site funding was supplemented by grants from the Wellington Hospital Research Office and the Austin Hospital Intensive Care Specialists Trust Fund.