Journal article

An enzyme-responsive controlled release system based on a dual-functional peptide

X Li, S Burger, AJ O'Connor, L Ong, JA Karas, SL Gras

CHEMICAL COMMUNICATIONS | ROYAL SOC CHEMISTRY | Published : 2016

Abstract

A new controlled release system was developed by loading a dual-functional peptide (DFP) on a mesoporous silica material. One-pot synthesis produced a DFP that was stimuli responsive, releasing a therapeutic peptide by protease cleavage. The design provides new steps towards smart biomaterials.

Grants

Awarded by ARC Dairy Innovation Hub


Funding Acknowledgements

We thank P. O'Donnell and C. S. Ang of The Bio21 Mass Spectrometry and Proteomics Facility for help with peptide characterisation; K. Ladewig and K. Abberton for advice on MMP; S. Boskovic for the code to determine the pore size distributions; R. Curtain of The University of Melbourne Advanced Microscopy Facility for SEM support; the PFPC for infrastructure access. X. Li is supported by a McKenzie fellowship and S. Gras by the ARC Dairy Innovation Hub IH120100005.