Journal article
Reticular pseudodrusen in intermediate age-related macular degeneration: Prevalence, detection, clinical, environmental, and genetic associations
Z Wu, LN Ayton, CD Luu, PN Baird, RH Guymer
Investigative Ophthalmology and Visual Science | Published : 2016
Abstract
PURPOSE. To determine the prevalence of reticular pseudodrusen (RPD) and their detection using multimodal imaging in patients with bilateral large drusen, and examine their clinical, demographic, environmental, and genetic associations. METHODS. Three hundred participants with bilateral large drusen (>125 µm) underwent color fundus photography (CFP), near-infrared reflectance (NIR), fundus autofluorescence (FAF), and spectral-domain optical coherence tomography (SD-OCT) imaging. Demographic information, smoking, and medical history were recorded, and a blood sample was obtained and genotyped to identify the risk alleles of the CFH and ARMS2 genes. RESULTS. Reticular pseudodrusen were detecte..
View full abstractGrants
Awarded by National Health and Medical Research Council (NHMRC)
Awarded by NHMRC Centre for Clinical Research Excellence Award
Funding Acknowledgements
Supported by National Health and Medical Research Council (NHMRC; Project Grant 1027624, Senior Research Fellowship 1028444 [PNB]), Macular Disease Foundation Australia Research Grant, Bupa Health Foundation (Australia), and BrightFocus Foundation. CERA receives operational infrastructure support from the Victorian government and is supported by an NHMRC Centre for Clinical Research Excellence Award (529923).