Journal article
People of the British Isles: Preliminary analysis of genotypes and surnames in a UK-control population
B Winney, A Boumertit, T Day, D Davison, C Echeta, I Evseeva, K Hutnik, S Leslie, K Nicodemus, EC Royrvik, S Tonks, X Yang, J Cheshire, P Longley, P Mateos, A Groom, C Relton, DT Bishop, K Black, E Northwood Show all
European Journal of Human Genetics | Published : 2012
Abstract
There is a great deal of interest in a fine-scale population structure in the UK, both as a signature of historical immigration events and because of the effect population structure may have on disease association studies. Although population structure appears to have a minor impact on the current generation of genome-wide association studies, it is likely to have a significant part in the next generation of studies designed to search for rare variants. A powerful way of detecting such structure is to control and document carefully the provenance of the samples involved. In this study, we describe the collection of a cohort of rural UK samples (The People of the British Isles), aimed at prov..
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Awarded by University of Exeter
Funding Acknowledgements
This project was funded by the Wellcome Trust, and we would like to acknowledge Lon Cardon and David Bicknell for their help in putting the grant application together. Sorrel May and Nick Godwin helped to kick start the large-scale recruitment of volunteers, while Chris Abell, Tanefa Apekey, Carolina Bonilla, Julie Burton, John Burns, Joy Hadfield, Christopher Hand, Amanda Howe, Pat Jonas, Ciaran Kilkelly, Donald Lehman, Julie Lewis, Louise Lynagh, Shan Owens, Jan Tawn, Malcolm Taylor and Stan Urbaniak were heavily involved in recruiting. This project was supported by the Peninsula NIHR Clinical Research Facility (University of Exeter) and the Wellcome Trust Clinical Research Facility (Manchester). Finally, we would like to thank all the volunteers themselves and the many friends and colleagues who helped to recruit them.