Journal article
Multiple Hodgkin lymphoma-associated loci within the HLA region at chromosome 6p21.3
L Moutsianas, V Enciso-Mora, YP Ma, S Leslie, A Dilthey, P Broderick, A Sherborne, R Cooke, A Ashworth, AJ Swerdlow, G McVean, RS Houlston
Blood | Published : 2011
Abstract
Since an association between the human leukocyte antigen (HLA) region and Hodgkin lymphoma (HL) was first reported in 1967, many studies have reported associations between HL risk and both single nucleotide polymorphism (SNP) and classic HLA allele variation in the major histocompatibility complex. However, population stratification and the extent and complexity of linkage disequilibrium within the major histocompatibility complex have hindered efforts to fine-map causal signals. Using SNP data to impute alleles at classic HLA loci, we have conducted an integrated analysis of HL risk within the HLA region in 582 early-onset HL cases and 4736 controls. We confirm that the strongest signal of ..
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Awarded by Medical Research Council
Funding Acknowledgements
This work was supported by the Leukemia and Lymphoma Research (United Kingdom), Cancer Research United Kingdom (C1298/A8362, supported by the Bobby Moore Fund), and the Wellcome Trust (awards 076113 and 085475). Sample and data acquisition was supported by Breakthrough Breast Cancer and the European Union. National Health Service funding was provided to the National Institute for Health Research Biomedical Research Center. This study made use of control genotyping data generated by the Wellcome Trust Case-Control Consortium. Genotype data were from the British 1958 Birth Cohort DNA collection (supported by the Medical Research Council grant G0000934 and the Wellcome Trust grant 068545/Z/02).