Journal article
A single-nucleotide polymorphism in the MicroRNA-146a gene is associated with diabetic nephropathy and sight-threatening diabetic retinopathy in Caucasian patients
G Kaidonis, MC Gillies, S Abhary, E Liu, RW Essex, JH Chang, B Pal, S Sivaprasad, M Pefkianaki, M Daniell, S Lake, N Petrovsky, AW Hewitt, A Jenkins, EL Lamoureux, JM Gleadle, JE Craig, KP Burdon
Acta Diabetologica | Published : 2016
Abstract
Aims: This study aimed to investigate whether the single-nucleotide polymorphism (SNP) rs2910164 residing within microRNA-146a (miR-146a) is associated with diabetic microvascular complications diabetic nephropathy (DN), proliferative diabetic retinopathy (PDR) or diabetic macular oedema (DME) in either Caucasian patients with type 1 (T1DM) or type 2 (T2DM) diabetes mellitus. Methods: Caucasian patients with T1DM (n = 733) or T2DM (n = 2215) were recruited from ophthalmology, renal and endocrine clinics in Australia and the UK. Patients with T2DM were required to have diabetes mellitus (DM) for at least 5 years and be on treatment with oral hypoglycaemic drugs or insulin. In total, 890 parti..
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Awarded by National Institute for Health Research
Funding Acknowledgements
This work was funded by a National Health and Medical Research Council (NHMRC) of Australia project Grant (#595918), the National Institute for Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology. The sponsor or funding organisation had no role in the design or conduct of this research. GK is funded by an NHMRC Clinical Research Postgraduate Scholarship and an Avant Doctor in Training Research Scholarship. Jamie Craig is supported in part by an NHMRC Practitioner Fellowship and Kathryn Burdon by an NHMRC Senior Research Fellowship.