Genomic Evidence for a Globally Distributed, Bimodal Population in the Ovine Footrot Pathogen Dichelobacter nodosus
Ruth M Kennan, Marianne Gilhuus, Sara Frosth, Torsten Seemann, Om P Dhungyel, Richard J Whittington, John D Boyce, David R Powell, Anna Aspan, Hannah J Jorgensen, Dieter M Bulach, Julian I Rood
MBIO | AMER SOC MICROBIOLOGY | Published : 2014
UNLABELLED: Footrot is a contagious, debilitating disease of sheep, causing major economic losses in most sheep-producing countries. The causative agent is the Gram-negative anaerobe Dichelobacter nodosus. Depending on the virulence of the infective bacterial strain, clinical signs vary from a mild interdigital dermatitis (benign footrot) to severe underrunning of the horn of the hoof (virulent footrot). The aim of this study was to investigate the genetic relationship between D. nodosus strains of different phenotypic virulences and between isolates from different geographic regions. Genome sequencing was performed on 103 D. nodosus isolates from eight different countries. Comparison of the..View full abstract
Awarded by Research Council of Norway
Research at the Norwegian Veterinary Institute and at Monash University was financially supported by a grant from the Research Council of Norway (project 199422). Research at Monash University was supported by the Australian Research Council (ARC), which provided funding to the ARC Centre of Excellence in Structural and Functional Microbial Genomics, and by the Victorian Life Sciences Computation Initiative, an initiative of the Victorian State Government. Research at the University of Sydney was supported by Australian Wool Innovation. The Swedish Farmers' Foundation for Agricultural Research is acknowledged for financial support.