Journal article
A genomic island in Salmonella enterica ssp. salamae provides new insights on the genealogy of the locus of enterocyte effacement
PS Chandry, S Gladman, SC Moore, T Seemann, KA Crandall, N Fegan
Plos One | Published : 2012
Abstract
The genomic island encoding the locus of enterocyte effacement (LEE) is an important virulence factor of the human pathogenic Escherichia coli. LEE typically encodes a type III secretion system (T3SS) and secreted effectors capable of forming attaching and effacing lesions. Although prominent in the pathogenic E. coli such as serotype O157:H7, LEE has also been detected in Citrobacter rodentium, E. albertii, and although not confirmed, it is likely to also be in Shigella boydii. Previous phylogenetic analysis of LEE indicated the genomic island was evolving through stepwise acquisition of various components. This study describes a new LEE region from two strains of Salmonella enterica subspe..
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Funding Acknowledgements
This study was supported by strategic research funds from CSIRO (The Commonwealth Scientific and Industrial Research Organisation)(http://www.csiro.au/) and Department of Primary Industries in Victoria (http://www.dpi.vic.gov.au/). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.