Journal article

Pseudomonas aeruginosa AES-1 Exhibits Increased Virulence Gene Expression during Chronic Infection of Cystic Fibrosis Lung

Sharna Naughton, Dane Parker, Torsten Seemann, Torsten Thomas, Lynne Turnbull, Barbara Rose, Peter Bye, Stuart Cordwell, Cynthia Whitchurch, Jim Manos

PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2011

Abstract

Pseudomonas aeruginosa, the leading cause of morbidity and mortality in people with cystic fibrosis (CF), adapts for survival in the CF lung through both mutation and gene expression changes. Frequent clonal strains such as the Australian Epidemic Strain-1 (AES-1), have increased ability to establish infection in the CF lung and to superimpose and replace infrequent clonal strains. Little is known about the factors underpinning these properties. Analysis has been hampered by lack of expression array templates containing CF-strain specific genes. We sequenced the genome of an acute infection AES-1 isolate from a CF infant (AES-1R) and constructed a non-redundant micro-array (PANarray) compris..

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University of Melbourne Researchers

Grants

Awarded by Australian Cystic Fibrosis Research Trust


Awarded by University of Sydney, Faculty of Medicine


Awarded by National Health and Medical Research Council of Australia


Funding Acknowledgements

This work was funded by The Australian Cystic Fibrosis Research Trust (ACFRT2006/BR) and the University of Sydney, Faculty of Medicine, Early Career Researcher Grant (ECR2009/JM) and the National Health and Medical Research Council of Australia Project, grant #632788. CW was funded by 22 a National Health and Medical Research Council (NHMRC) Career Development Award and a NHMRC Senior Research Fellowship. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.