Journal article
DOWN-MODULATION OF RECEPTORS FOR GRANULOCYTE COLONY-STIMULATING FACTOR ON HUMAN-NEUTROPHILS BY GRANULOCYTE-ACTIVATING AGENTS
NA NICOLA, MA VADAS, AF LOPEZ
JOURNAL OF CELLULAR PHYSIOLOGY | WILEY-LISS | Published : 1986
Abstract
Purified human blood neutrophils were able to bind radioiodinated murine granulocyte-colony-stimulating factor (G-CSF) in a specific manner. This factor has previously been shown to stimulate functional activities of human and murine neutrophilic granulocytes and to be functionally analogous to human-derived CSF beta. The binding of 125I G-CSF to human neutrophils was competed for equally by unlabeled G-CSF and CSF beta but not by other CSF's. Saturation analysis indicated that human neutrophils displayed about 700-1,500 receptors for G-CSF/CSF beta per cell. Three other agents (N-formyl-methionine-leucine phenylalanine, bacterial lipopolysaccharide, and human CSF alpha) known to activate ne..
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Awarded by NCI NIH HHS
Awarded by NIAID NIH HHS