Avian influenza viruses, inflammation, and CD8( ) T Cell immunity
Zhongfang Wang, Liyen Loh, Lukasz Kedzierski, Katherine Kedzierska
FRONTIERS IN IMMUNOLOGY | FRONTIERS MEDIA SA | Published : 2016
Avian influenza viruses (AIVs) circulate naturally in wild aquatic birds, infect domestic poultry, and are capable of causing sporadic bird-to-human transmissions. AIVs capable of infecting humans include a highly pathogenic AIV H5N1, first detected in humans in 1997, and a low pathogenic AIV H7N9, reported in humans in 2013. Both H5N1 and H7N9 cause severe influenza disease in humans, manifested by acute respiratory distress syndrome, multi-organ failure, and high mortality rates of 60% and 35%, respectively. Ongoing circulation of H5N1 and H7N9 viruses in wild birds and poultry, and their ability to infect humans emphasizes their epidemic and pandemic potential and poses a public health th..View full abstract
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Awarded by Medical Research Council (NHMRC) Program Grant
This work was supported by Australian National Health and Medical Research Council (NHMRC) Program Grant (AI1071916) to KK. KK is an NHMRC CDF2 Fellow (AI1023294).