Shape-Dependent Activation of Cytokine Secretion by Polymer Capsules in Human Monocyte-Derived Macrophages

Xi Chen; Yan Yan; Markus Muellner; Yuan Ping; Jiwei Cui; Kristian Kempe; Christina Cortez-Jugo; Frank Caruso

Journal article

Shape-Dependent Activation of Cytokine Secretion by Polymer Capsules in Human Monocyte-Derived Macrophages

Xi Chen, Yan Yan, Markus Muellner, Yuan Ping, Jiwei Cui, Kristian Kempe, Christina Cortez-Jugo, Frank Caruso

BIOMACROMOLECULES | AMER CHEMICAL SOC | Published : 2016

DOI: 10.1021/acs.biomac.6b00027

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Abstract

Particles with tailored geometries have received significant attention due to their specific interactions with biological systems. In this work, we examine the effect of polymer capsule shape on cytokine secretion by human monocyte-derived macrophages. Thiolated poly(methacrylic acid) (PMASH) polymer capsules with different shapes (spherical, short rod-shaped, and long rod-shaped) were prepared by layer-by-layer assembly. The effect of PMASH capsule shape on cellular uptake and cytokine secretion by macrophages differentiated from THP-1 monocytes (dTHP-1) was investigated. PMASH capsules with different shapes were internalized to a similar extent in dTHP-1 cells. However, cytokine secretion ..

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University of Melbourne Researchers

Christina Cortez-Jugo Author Chemical Engineering

Frank Caruso Author Chemical Engineering

Jiwei Cui Author Chemical Engineering

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Grants

Awarded by Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology

Awarded by ARC under the Australian Laureate Fellowship

Awarded by Discovery Early Career Researcher Award

Awarded by Super Science Fellowship

Funding Acknowledgements

This research was conducted through and funded by the Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology (project number CE140100036). This work was also supported by the ARC under the Australian Laureate Fellowship (F.C., FL120100030), Discovery Early Career Researcher Award (Y.Y., DE130100488), and Super Science Fellowship (F.C., FS110200025) schemes. M.M. thanks the University of Melbourne for support through the McKenzie Fellowship. K.K. is grateful to the Alexander von Humboldt-foundation for a Feodor-Lynen fellowship. The authors thank Ka Fung Noi and Qiong Dai (the University of Melbourne) for assistance with capsule preparation. This work was performed in part at the Materials Characterisation and Fabrication Platform (MCFP) at the University of Melbourne and the Victorian Node of the Australian National Fabrication Facility (ANFF).