Journal article

TGF-beta receptor type II and fetuin in the developing sheep neocortex

KM Dziegielewska, RT Williams, GW Knott, PD Kitchener, SE Monk, A Potter, NR Saunders

CELL AND TISSUE RESEARCH | SPRINGER VERLAG | Published : 1997

Abstract

Fetuin shows a characteristic pattern of distribution in the developing neocortex in many mammalian species. Its expression is confined to early-appearing cortical-plate and later subplate neurons. A short 19 amino-acid sequence of fetuin shows a degree of homology to an 18 amino-acid sequence of the TGF-beta type II receptor (TbetaR-II) and in vitro fetuin binds to members of the TGF-beta family of cytokines. It has been suggested that fetuin is the biologically significant antagonist of these cytokines. We have compared, using immunocytochemistry, the distribution pattern of TbetaR-II and fetuin in the developing neocortex of foetal sheep. TbetaR-II immunoreactivity first appears at around..

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