The Wilms' tumour suppressor protein, WT1, undergoes CRM1-independent nucleocytoplasmic shuttlingy

Abstract

The Wilms' tumour suppressor gene (WT1) encodes a zinc finger-containing nuclear protein essential for kidney and urogenital development. Initially considered a transcription factor, there is mounting evidence that WT1 has a role in post-transcriptional processing. Using the interspecies heterokaryon assay, we have demonstrated that WT1 can undergo nucleocytoplasmic shuttling. We have also mapped the region responsible for nuclear export to residues 182-324. Our data add further complexity to the role of WT1 in trancriptional and post-transcriptional regulation. © 2003 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.