Journal article
Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination
D Bogani, P Siggers, R Brixey, N Warr, S Beddow, J Edwards, D Williams, D Wilhelm, P Koopman, RA Flavell, H Chi, H Ostrer, S Wells, M Cheeseman, A Greenfield
Plos Biology | PUBLIC LIBRARY SCIENCE | Published : 2009
Abstract
Sex determination in mammals is controlled by the presence or absence of the Y-linked gene SRY. In the developing male (XY) gonad, sex-determining region of the Y (SRY) protein acts to up-regulate expression of the related gene, SOX9, a transcriptional regulator that in turn initiates a downstream pathway of testis development, whilst also suppressing ovary development. Despite the requirement for a number of transcription factors and secreted signalling molecules in sex determination, intracellular signalling components functioning in this process have not been defined. Here we report a role for the phylogenetically ancient mitogen-activated protein kinase (MAPK) signalling pathway in mouse..
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Awarded by Medical Research Council
Funding Acknowledgements
This research was supported by Core Funding to AG at the Medical Research Council (MRC) Mammalian Genetics Unit, Harwell, United Kingdom (U.1426.00.004.00001.01). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.