Journal article

Parathyroid Hormone Inhibits c-Jun N-Terminal Kinase Activity in Rat Osteoblastic Cells by a Protein Kinase A-Dependent Pathway

Teresa A Doggett, John T Swarthout, Stephen C Jefcoat, Dagmar Wilhelm, Andreas Dieckmann, Peter Angel, Nicola C Partridge

Endocrinology | The Endocrine Society | Published : 2002


Abstract Treatment of osteoblastic cells with PTH initiates dual signaling cascades resulting in activation of both PKA and PKC. It has been shown that PTH either inhibits or stimulates ERKs depending on dose of the hormone; nevertheless, the ability of PTH to regulate other members of the MAPK family is unknown. Another member of this family, c-Jun-NH2-terminal kinase (JNK), is preferentially activated by cytokines and cellular stresses and plays a key role in regulating the activity of various transcription factors. We demonstrate that treatment of UMR 106-01 cells and rat calvarial osteoblasts with PTH (10−8m), N-terminal peptides of PTH that selectively activate PKA, or 8-..

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University of Melbourne Researchers


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