Journal article

Modeling human osteosarcoma in the mouse: From bedside to bench

Katherine A Janeway, Carl R Walkley

Bone | ELSEVIER SCIENCE INC | Published : 2010

Abstract

Osteosarcoma (OS) is the most common primary tumour of bone, occurring predominantly in the second decade of life. High-dose cytotoxic chemotherapy and surgical resection have improved prognosis, with long-term survival for patients with localized (non-metastatic) disease approaching 70%. At presentation approximately 20% of patients have metastases and almost all patients with recurrent OS have metastatic disease and cure rates for patients with metastatic or recurrent disease remain poor (<20% survival). Over the past 20 years, considerable progress has been made in the understanding of OS pathogenesis, yet these insights have not translated into substantial therapeutic advances and clinic..

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Grants

Funding Acknowledgements

We thank Dr Tony Mutsaers for critical reading and comment Work in C.R.W's laboratory is supported by grants from the NHMRC of Australia. C.R.W. was a Special Fellow of the Leukemia & Lymphoma Society, an NHMRC Career Development Award holder and is the Leukaemia Foundation Phillip Desbrow Senior Research Fellow.