The role of vitamin A and retinoic acid receptor signaling in post-natal maintenance of bone
Alanna C Green, T John Martin, Louise E Purton
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2016
Vitamin A and retinoid derivatives are recognized as morphogens that govern body patterning and skeletogenesis, producing profound defects when in excess. In post-natal bone, both high and low levels of vitamin A are associated with poor bone heath and elevated risk of fractures. Despite this, the precise mechanism of how retinoids induce post-natal bone changes remains elusive. Numerous studies have been performed to discover how retinoids induce these changes, revealing a complex morphogenic regulation of bone through interplay of different cell types. This review will discuss the direct and indirect effects of retinoids on mediators of bone turnover focusing on differentiation and activit..View full abstract
This work was supported in part by the Operational Infrastructure Support Scheme from the Victorian State Government (to St. Vincent's Institute). L.E.P is a Senior Research Fellow of the NHMRC.