Book Chapter

Signaling in Bone

TJ Martin, NA Sims

Dynamics of Bone and Cartilage Metabolism | Published : 2006


This chapter proposes that transiently activated ostoclasts can contribute to the coupling of bone formation to resorption by producing an activity that influences preostoblast participation in bone formation. Circulating hormones and locally generated cytokines and growth factors control the activities of ostoblasts and ostoclasts to form and resorb bone. The latter are especially important, comprising complex signaling systems in bone that determine how bone is formed and resorbed in the remodeling process. Cells of ostoblast lineage regulate ostoclast formation from hemopoietic precursors through contact-dependent mechanisms that are controlled by hormones and by the production of locally..

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