Journal article
Oxidized limonene and oxidized linalool - Concomitant contact allergy to common fragrance terpenes
J Bråred Christensson, AT Karlberg, KE Andersen, M Bruze, JD Johansen, B Garcia-Bravo, A Giménez Arnau, CL Goh, R Nixon, IR White
Contact Dermatitis | WILEY | Published : 2016
DOI: 10.1111/cod.12545
Abstract
Summary Background Limonene and linalool are common fragrance terpenes. Both oxidized R-limonene and oxidized linalool have recently been patch tested in an international setting, showing contact allergy in 5.2% and 6.9% of dermatitis patients, respectively. Objective To investigate concomitant reactions between oxidized R-limonene and oxidized linalool in consecutive dermatitis patients. Methods Oxidized R-limonene 3.0% (containing limonene hydroperoxides 0.33%) and oxidized linalool 6% (linalool hydroperoxides 1%) in petrolatum were tested in 2900 consecutive dermatitis patients in Australia, Denmark, Singapore, Spain, Sweden, and the United Kingdom. Results A total of 281 patients reacted..
View full abstractGrants
Funding Acknowledgements
We thank Marie Norback for administrative assistance. Katarina Emilsson, Charlotte Siwmark and Bo Niklasson at Chemotechnique Diagnostics AB Vellinge, Sweden, are acknowledged for chemical analysis and preparation of the patch test materials of oxidized limonene and oxidized linalool. The work was financially supported by the Swedish Asthma and Allergy Association, Stockholm, Sweden, Hudfonden (the Welander-Finsen Foundation), Stockholm, Sweden, and the Health & Medical Care Committee of the Region Vastra Gotaland (ALF), Sweden. The work was performed in the Centre for Skin Research (SkinResQU), University of Gothenburg, Sweden.