Rare genetic variants: making the connection with breast cancer susceptibility
Tu Nguyen-Dumont, Jenna Stewart, Ingrid Winship, Melissa C Southey
AIMS GENETICS | AMER INST MATHEMATICAL SCIENCES-AIMS | Published : 2015
AbstractThe practice of clinical genetics in the context of breast cancer predisposition has reached another critical point in its evolution. For the past two decades, genetic testing offered to women attending clinics has been limited to BRCA1 and BRCA2 unless other syndromic indicators have been evident (e.g. PTEN and TP53 for Cowden and Li-Fraumeni syndrome, respectively). Women (and their families) who are concerned about their personal and/or family history of breast and ovarian cancer have enthusiastically engaged with clinical genetics services, anticipating a genetic cause for their cancer predisposition will be identified and to receive clinical guidance for their risk management an..View full abstract
M.C.S is a National Health and Medical Research Council Senior Research Fellow. J.S. is a recipient of a Department of Pathology, The University of Melbourne, Honours student scholarship.