Journal article
Marsupials and monotremes possess a novel family of MHC class I genes that is lost from the eutherian lineage
AT Papenfuss, ZP Feng, K Krasnec, JE Deakin, ML Baker, RD Miller
BMC Genomics | Published : 2015
Abstract
Major histocompatibility complex (MHC) class I genes are found in the genomes of all jawed vertebrates. The evolution of this gene family is closely tied to the evolution of the vertebrate genome. Family members are frequently found in four paralogous regions, which were formed in two rounds of genome duplication in the early vertebrates, but in some species class Is have been subject to additional duplication or translocation, creating additional clusters. The gene family is traditionally grouped into two subtypes: classical MHC class I genes that are usually MHC-linked, highly polymorphic, expressed in a broad range of tissues and present endogenously-derived peptides to cytotoxic T-cells;..
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Awarded by National Science Foundation
Funding Acknowledgements
We thank Chris Davoren for technical assistance. ATP was supported by a National Health and Medical Research Council (NHMRC) Career Development Fellowship [1003856] and an NHMRC Program Grant [1054618]. KK and RDM were supported by awards from the U.S. National Science Foundation [IOS-0641382 and IOS-1353123] and U.S. National Institutes of Health, Institutional Development Award program [P20GM103452 and P30GM110907]. The work benefitted from support by the Victorian State Government Operational Infrastructure Support and Australian Government NHMRC Independent Research Institute Infrastructure Support Scheme.