Journal article

Associations between the IASLC/ATS/ERS lung adenocarcinoma classification and EGFR and KRAS mutations

TD Clay, PA Russell, H Do, V Sundararajan, M Conron, GM Wright, A Dobrovic, MM Moore, SA McLachlan

PATHOLOGY | ELSEVIER SCIENCE BV | Published : 2016

Abstract

We sought to investigate the frequency of mutations in epidermal growth factor receptor (EGFR) and Kirsten-RAS (KRAS) by each pathological subtype for patients with resected pulmonary adenocarcinoma as defined by the IASLC/ATS/ERS classification. Histological examination determined the predominant subtype according to the IASLC/ATS/ERS classification. EGFR and KRAS mutations were determined by high-resolution melting and Sanger sequencing. Clinical data were collected from medical records and clinicians. The 178 consecutive patients consisted of 48% males, median age 68 years (range 20-87) and smoking history 78%. The tumour stage was I in 62%, II in 18% and III in 20%. The mutation rates we..

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