Spectral distribution of local field potential responses to electrical stimulation of the retina

Yan T Wong; Kerry Halupka; Tatiana Kameneva; Shaun L Cloherty; David B Grayden; Anthony N Burkitt; Hamish Meffin; Mohit N Shivdasani

Journal article

Spectral distribution of local field potential responses to electrical stimulation of the retina

Yan T Wong, Kerry Halupka, Tatiana Kameneva, Shaun L Cloherty, David B Grayden, Anthony N Burkitt, Hamish Meffin, Mohit N Shivdasani

JOURNAL OF NEURAL ENGINEERING | IOP PUBLISHING LTD | Published : 2016

DOI: 10.1088/1741-2560/13/3/036003

Abstract

OBJECTIVE: Different frequency bands of the local field potential (LFP) have been shown to reflect neuronal activity occurring at varying cortical scales. As such, recordings of the LFP may offer a novel way to test the efficacy of neural prostheses and allow improvement of stimulation strategies via neural feedback. Here we use LFP measurements from visual cortex to characterize neural responses to electrical stimulation of the retina. We aim to show that the LFP is a viable signal that contains sufficient information to optimize the performance of sensory neural prostheses. APPROACH: Clinically relevant electrode arrays were implanted in the suprachoroidal space of one eye in four felines...

View full abstract

University of Melbourne Researchers

Hamish Meffin Author Biomedical Engineering

Tania Kameneva Author

David Grayden Author Biomedical Engineering

Anthony Burkitt Author Biomedical Engineering

Related Projects (8)

NEURO-FEEDBACK FOR IMPROVED EFFICACY OF RETINAL PROSTHESES

Bionic eyes offer the possibility to return sight to the blind. Existing retinal implants are effective at delivering basic visual percepts,..

NEXT GENERATION CYBERNETICS: LONG TERM CARBON FIBRE DUAL STIMULATION / RECORDING ELECTRODE ARRAYS FOR CLOSED LOOP NEURAL IMPLANTS

Electrodes implanted in the brain have enormous potential for treating a range of conditions from epilepsy to control of prosthetics for pat..

Neural Activity Shaping for Retinal and Cochlear Implants

This project aims to develop methods to control and optimise the spatial patterns of neural activity evoked by neural prostheses in order to..

NEXT GENERATION CYBERNETICS: LONG TERM CARBON FIBRE DUAL STIMULATION / RECORDING ELECTRODE ARRAYS FOR CLOSED LOOP NEURAL IMPLANTS

Electrodes implanted in the brain have enormous potential for treating a range of conditions from epilepsy to control of prosthetics for pat..

DEVELOPMENT OF A HIGH ACUITY, DIAMOND RETINAL PROSTHESIS

Over recent years our team has developed a retinal implant to restore sight to people with certain types of blindness. With 256 independentl..

DEVELOPMENT OF A HIGH ACUITY, DIAMOND RETINAL PROSTHESIS

Over recent years our team has developed a retinal implant to restore sight to people with certain types of blindness. With 256 independentl..

NEXT GENERATION CYBERNETICS: LONG TERM CARBON FIBRE DUAL STIMULATION / RECORDING ELECTRODE ARRAYS FOR CLOSED LOOP NEURAL IMPLANTS

Electrodes implanted in the brain have enormous potential for treating a range of conditions from epilepsy to control of prosthetics for pat..

BIONIC VISION AUSTRALIA

Bionic Vision Australia’s retinal implant will provide vision to blind patients suffering fromdegenerative retinal conditions, including age..

Grants

Awarded by Australian Research Council's Discovery Projects funding scheme

Awarded by Special Research Initiative (SRI) in Bionic Vision Science and Technology

Awarded by National Health and Medical Research Council Australia

Awarded by Victorian Life Sciences Computation Initiative (VLSCI) of the Victorian Government, Australia

Funding Acknowledgements

The authors wish to thank Felix Aplin, Patrick Atkinson, Rosemary Cicione, Sam John, and Ronald Leung for assistance with data collection, Michelle McPhedran and Alexia Saunders for technical assistance, Penelope Allen and Jonathan Yeoh who performed all surgeries, and Owen Burns, Helen Feng, and Vanessa Maxim for electrode array fabrication. We also wish to thank Rob Shepherd, Chris Williams and James Fallon for overall guidance and advice during the in vivo experiments. This research was supported by the Australian Research Council's Discovery Projects funding scheme (DP140104533) and through its Special Research Initiative (SRI) in Bionic Vision Science and Technology awarded to Bionic Vision Australia (BVA) SR1000005. The contribution of MNS was funded by a project grant from the National Health and Medical Research Council Australia (GNT1063093). The research was also supported by the Bertalli Family Foundation through the Bionics Institute. The Bionics Institute acknowledges the support received from the Victorian Government through its Operational Infrastructure Program. This research was supported by a Victorian Life Sciences Computation Initiative (VLSCI) grant number [VR0138] on its Peak Computing Facility at the University of Melbourne, an initiative of the Victorian Government, Australia.