Journal article

Therapeutics for Childhood Neurofibromatosis Type 1 and Type 2

Simone L Ardern-Holmes, Kathryn N North

Current Treatment Options in Neurology | CURRENT MEDICINE GROUP | Published : 2011

Abstract

OPINION STATEMENT: Neurofibromatosis type 1 (NF1) and type 2 (NF2) are genetically and medically distinct neurocutaneous disorders that are both associated with tumors affecting the central and peripheral nervous systems. NF1 has a frequency of 1 in 3,000, compared with 1 in 30,000 for NF2. Careful surveillance is important for both conditions, to allow early identification and treatment of complications. The most common and important problems in NF1 are cognitive impairment, optic pathway gliomas, plexiform neurofibromas, and orthopaedic issues. Early intervention and tailored educational programs are indicated for learning difficulties. Attention deficit hyperactivity disorder may be amena..

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