Exploration of the P-3 region of PEXEL peptidomimetics leads to a potent inhibitor of the Plasmodium protease, plasmepsin V

Michelle Gazdik; Kate E Jarman; Matthew T O'Neill; Anthony N Hodder; Kym N Lowes; Helene Jousset Sabroux; Alan F Cowman; Justin A Boddey; Brad E Sleebs

Journal article

Exploration of the P-3 region of PEXEL peptidomimetics leads to a potent inhibitor of the Plasmodium protease, plasmepsin V

Michelle Gazdik, Kate E Jarman, Matthew T O'Neill, Anthony N Hodder, Kym N Lowes, Helene Jousset Sabroux, Alan F Cowman, Justin A Boddey, Brad E Sleebs

Bioorganic & Medicinal Chemistry | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2016

DOI: 10.1016/j.bmc.2016.03.027

University of Melbourne Researchers

Anthony Hodder Author Medical Biology (W.E.H.I.)

Kym Lowes Author Medical Biology (W.E.H.I.)

Helene Jousset Sabroux Author Medical Biology (W.E.H.I.)

Alan Cowman Author Medical Biology (W.E.H.I.)

Justin Boddey Author Medical Biology (W.E.H.I.)

Grants

Awarded by National Health and Medical Research Council of Australia

Funding Acknowledgements

This work was funded by the National Health and Medical Research Council of Australia ( Project Grant 1010326 to J. A. B., Program Grant 1092789 to A. F. C.), the Australian Cancer Research Foundation, the Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIISS. We thank the University of Melbourne for the provision of an Australian Postgraduate Award to M. G. A. F. C. is a Howard Hughes International Scholar and an Australia Fellow of the NHMRC. J. A. B. is an Australian Research Council QEII Fellow.