Journal article
Global genomic diversity of human papillomavirus 11 based on 433 isolates and 78 complete genome sequences
MM Jelen, Z Chen, BJ Kocjan, L Hošnjak, FJ Burt, PKS Chan, D Chouhy, CE Combrinck, C Estrade, A Fiander, SM Garland, AA Giri, JV González, A Gröning, S Hibbitts, TNM Luk, K Marinic, T Matsukura, A Neumann, A Oštrbenk Show all
Journal of Virology | Published : 2016
DOI: 10.1128/JVI.03149-15
Abstract
Human papillomavirus 11 (HPV11) is an etiological agent of anogenital warts and laryngeal papillomas and is included in the 4-valent and 9-valent prophylactic HPV vaccines. We established the largest collection of globally circulating HPV11 isolates to date and examined the genomic diversity of 433 isolates and 78 complete genomes (CGs) from six continents. The genomic variation within the 2,800-bp E5a-E5b-L1-upstream regulatory region was initially studied in 181/207 (87.4%) HPV11 isolates collected for this study. Of these, the CGs of 30 HPV11 variants containing unique single nucleotide polymorphisms (SNPs), indels (insertions or deletions), or amino acid changes were fully sequenced. A m..
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Awarded by National Institutes of Health
Funding Acknowledgements
This work, including the efforts of Mateja M. Jelen, was funded by Slovenian Research Agency (1000-10-310163). This work, including the efforts of Lea Hosnjak, Anja Ostrbenk, and Mario Poljak, was funded by European Commission FP7 Program (603019). This work, including the efforts of Mario Poljak, was funded by Merck Sharp and Dohme (research grant). This work, including the efforts of Robert D. Burk, was funded by HHS vertical bar NIH vertical bar National Cancer Institute (NCI) (CA78527 and P30CA013330). This work, including the efforts of Robert D. Burk, was funded by HHS vertical bar National Institutes of Health (NIH) (AI-51519). This work, including the efforts of Mateja M. Jelen, was funded by European Society of Clinical Microbiology and Infectious Diseases (ESCMID) (research grant 2014).