Journal article

Structural connectivity relates to perinatal factors and functional impairment at 7 years in children born very preterm

Deanne K Thompson, Jian Chen, Richard Beare, Christopher L Adamson, Rachel Ellis, Zohra M Ahmadzai, Claire E Kelly, Katherine J Lee, Andrew Zalesky, Joseph YM Yang, Rodney W Hunt, Jeanie LY Cheong, Terrie E Inder, Lex W Doyle, Marc L Seal, Peter J Anderson

NEUROIMAGE | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2016

Abstract

OBJECTIVE: To use structural connectivity to (1) compare brain networks between typically and atypically developing (very preterm) children, (2) explore associations between potential perinatal developmental disturbances and brain networks, and (3) describe associations between brain networks and functional impairments in very preterm children. METHODS: 26 full-term and 107 very preterm 7-year-old children (born <30weeks' gestational age and/or <1250g) underwent T1- and diffusion-weighted imaging. Global white matter fibre networks were produced using 80 cortical and subcortical nodes, and edges were created using constrained spherical deconvolution-based tractography. Global graph theory me..

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Grants

Awarded by Australia's National Health and Medical Research Council (Centre for Clinical Research Excellence)


Awarded by National Institutes of Health


Awarded by Royal Children's Hospital Foundation


Awarded by EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT


Funding Acknowledgements

This work was supported by Australia's National Health and Medical Research Council (Centre for Clinical Research Excellence 546519 to LD, PA, TI, RH and JLYC; Centre for Research Excellence 1060733 to LD, PA, RH, JLYC and DT; Project grants 237117 to LD, 491209 to PA; Senior Research Fellowship 1081288 to PA; Career Development Fellowship 1085754 to DT; Early Career Fellowships 1012236 to DT, 1053787 to JLYC; Postgraduate Scholarship 1039160 to JY), National Institutes of Health (HD058056), United Cerebral Palsy Foundation (USA), Leila Y. Mathers Charitable Foundation (USA), the Brown Foundation (USA), the Victorian Government's Operational Infrastructure Support Programme, and The Royal Children's Hospital Foundation (RCH1000 to JY).