Ablation of Type-1 IFN Signaling in Hematopoietic Cells Confers Protection Following Traumatic Brain Injury
Ila P Karve, Moses Zhang, Mark Habgood, Tony Frugier, Kate M Brody, Maithili Sashindranath, C Joakim Ek, Stephane Chappaz, Ben T Kile, David Wright, Hong Wang, Leigh Johnston, Maria Daglas, Robert C Ates, Robert L Medcalf, Juliet M Taylor, Peter J Crack
ENEURO | SOC NEUROSCIENCE | Published : 2016
Type-1 interferons (IFNs) are pleiotropic cytokines that signal through the type-1 IFN receptor (IFNAR1). Recent literature has implicated the type-1 IFNs in disorders of the CNS. In this study, we have investigated the role of type-1 IFNs in neuroinflammation following traumatic brain injury (TBI). Using a controlled cortical impact model, TBI was induced in 8- to 10-week-old male C57BL/6J WT and IFNAR1(-/-) mice and brains were excised to study infarct volume, inflammatory mediator release via quantitative PCR analysis and immune cell profile via immunohistochemistry. IFNAR1(-/-) mice displayed smaller infarcts compared with WT mice after TBI. IFNAR1(-/-) mice exhibited an altered anti-inf..View full abstract
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Awarded by National Health and Medical Research Council of Australia
This work was supported by National Health and Medical Research Council of Australia Project Grant 628391 (PJC) and Project Grant 1044714 (PJC, JMT), an Australian Research Council Future Fellowship (PJC) and the Rebecca Cooper Foundation.