Journal article
The effects of maternal anxiety during pregnancy on IGF2/H19 methylation in cord blood
T Mansell, B Novakovic, B Meyer, P Rzehak, P Vuillermin, AL Ponsonby, F Collier, D Burgner, R Saffery, J Ryan
Translational Psychiatry | Published : 2016
DOI: 10.1038/tp.2016.32
Abstract
Compelling evidence suggests that maternal mental health in pregnancy can influence fetal development. The imprinted genes, insulin-like growth factor 2 (IGF2) and H19, are involved in fetal growth and each is regulated by DNA methylation. This study aimed to determine the association between maternal mental well-being during pregnancy and differentially methylated regions (DMRs) of IGF2 (DMR0) and the IGF2/H19 imprinting control region (ICR) in newborn offspring. Maternal depression, anxiety and perceived stress were assessed at 28 weeks of pregnancy in the Barwon Infant Study (n=576). DNA methylation was measured in purified cord blood mononuclear cells using the Sequenom MassArray Platfor..
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Awarded by British Interplanetary Society
Funding Acknowledgements
The Barwon Infant Study is supported by a National Health and Medical Research Council (NHMRC) Project Grant and the Victorian Government's Operational Infrastructure Support Program. This project was supported by the Preston and Loui Geduld Trust Fund, managed by Equity Trustees (grant to JR), as well as partial support from the Commission of the European Communities, the 7th Framework Programme, contract FP7-289346-EARLY NUTRITION, and an NHMRC: EU project (APP1038018 to RS). This work was also supported by an Australian Postgraduate Award University of Melbourne (to TM), NHMRC Senior Research Fellowships (APP1008396 to A-LP; APP1045161 to RS); and an NHMRC Early Career Researcher Fellowship (APP1012735 to JR). We acknowledge and thank the BIS research staff and the participants. The funders had no role in the design and conduct of the study; in data collection, management, analysis or interpretation of the data; and were not involved with the writing, preparation, review or approval of the manuscript.