Journal article

Genome-wide significant results identified for plasma apolipoprotein H levels in middle-aged and older adults

Karen A Mather, Anbupalam Thalamuthu, Christopher Oldmeadow, Fei Song, Nicola J Armstrong, Anne Poljak, Elizabeth G Holliday, Mark McEvoy, John B Kwok, Amelia A Assareh, Simone Reppermund, Nicole A Kochan, Teresa Lee, David Ames, Margaret J Wright, Julian N Trollor, Peter W Schofield, Henry Brodaty, Rodney J Scott, Peter R Schofield Show all



Apolipoprotein H (ApoH) is a multi-functional plasma glycoprotein that has been associated with negative health outcomes. ApoH levels have high heritability. We undertook a genome-wide association study of ApoH levels using the largest sample to date and replicated the results in an independent cohort (total N = 1,255). In the discovery phase, a meta-analysis of two cohorts, the Sydney Memory and Ageing Study (Sydney MAS) and the Older Australian Twins Study (OATS) (n = 942) revealed genome-wide significant results in or near the APOH gene on chromosome 17 (top SNP, rs7211380, p = 1 × 10(-11)). The results were replicated in an independent cohort, the Hunter Community Study (p < 0.002) (n = ..

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University of Melbourne Researchers


Awarded by National Health and Medical Research Council (NHMRC)/Australian Research Council Strategic Award

Awarded by NHMRC

Awarded by NHMRC Enabling Grant

Funding Acknowledgements

We would like to thank the Sydney MAS, OATS, HCS participants and their respective research teams. Plasma ApoH assays were performed using facilities provided by the UNSW Bioanalytical Mass Spectrometry Facility in the School of Medical Sciences, UNSW Australia. Access to these facilities is gratefully acknowledged. Sydney MAS and OATS were supported by a National Health and Medical Research Council (NHMRC)/Australian Research Council Strategic Award (Grant 401162) and NHMRC Program Grants (350833, 568969) and a Project Grant (1045325). OATS was facilitated through access to the Australian Twin Registry, which is funded by the NHMRC Enabling Grant 310667. DNA was extracted by Genetic Repositories Australia, which was funded by the NHMRC Enabling Grant 401184. OATS genotyping was partly funded by a Commonwealth Scientific and Industrial Research Organisation Flagship Collaboration Fund Grant. The HCS is supported by the University of Newcastle and the Fairfax Family Foundation. The apolipoprotein assay work was in part supported by funding from the Rebecca L. Cooper Medical Research Foundation, which is gratefully acknowledged.