Journal article
Aβ-related memory decline in APOE ϵ4 noncarriers: Implications for Alzheimer disease
YY Lim, SM Laws, VL Villemagne, RH Pietrzak, T Porter, D Ames, C Fowler, S Rainey-Smith, PJ Snyder, RN Martins, O Salvado, P Bourgeat, CC Rowe, CL Masters, P Maruff
Neurology | Published : 2016
Abstract
Objective: As the absence of Aβ-related memory decline in APOE ϵ4 noncarriers may be due to the relative brevity of previous studies, we aimed to characterize Aβ-related cognitive decline over 72 months in APOE ϵ4 carriers and noncarriers who were cognitively normal (CN). Methods: CN older adults (n 423) underwent Aβ imaging and APOE genotyping. Participants completed comprehensive neuropsychological testing at baseline 18-, 36-, 54-, and 72-month assessments. Results: Relative to Aβ- CN ϵ4 noncarriers, both Aβ+ CN ϵ4 carriers and noncarriers showed significantly increased decline in measures of memory, language, and executive function as well as higher rates of progression to a clinical cla..
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Funding Acknowledgements
Funding for the study was provided in part by the study partners (Commonwealth Scientific Industrial and research Organization [CSIRO], Edith Cowan University [ECU], Mental Health Research institute [MHRI], National Ageing Research Institute [NARI], Austin Health, CogState Ltd.). The study also received support from the National Health and Medical Research Council (NHMRC) and the Dementia Collaborative Research Centres program (DCRC2), as well as funding from the Science and Industry Endowment Fund (SIEF) and the Cooperative Research Centre (CRC) for Mental Health, an Australian Government Initiative. Y.Y.L. is currently funded by the Alzheimer's Australia Dementia Research Fellowship and the Yulgilbar Foundation.