Evolution of Protein Quaternary Structure in Response to Selective Pressure for Increased Thermostability

Nicholas J Fraser; Jian-Wei Liu; Peter D Mabbitt; Galen J Correy; Chris W Coppin; Mathilde Lethier; Matthew A Perugini; James M Murphy; John G Oakeshott; Martin Weik; Colin J Jackson

Journal article

Evolution of Protein Quaternary Structure in Response to Selective Pressure for Increased Thermostability

Nicholas J Fraser, Jian-Wei Liu, Peter D Mabbitt, Galen J Correy, Chris W Coppin, Mathilde Lethier, Matthew A Perugini, James M Murphy, John G Oakeshott, Martin Weik, Colin J Jackson

Journal of Molecular Biology | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2016

DOI: 10.1016/j.jmb.2016.03.014

University of Melbourne Researchers

Matt Perugini Author Biochemistry and Molecular Biology

James Murphy Author Medical Biology (W.E.H.I.)

Grants

Awarded by USA Defense Threat Reduction Agency

Awarded by NHMRC IRIISS grant

Funding Acknowledgements

C.J.J. thanks the Australian Research Council for a Future Fellowship. P.D.M. thanks the Science and Industry Endowment Fund for a John Stocker Fellowship. We acknowledge the La Trobe University-Comprehensive Proteomics Platform for access to essential equipment employed in this study. This work was supported by a grant from the USA Defense Threat Reduction Agency HDTRA1-11-C-0047. J.M.M. acknowledges additional support from NHMRC IRIISS grant 9000220 and the Victorian Government Operational Infrastructure Support scheme. We thank staff at the Australian Synchrotron SAXS beamline for help with data collection.