Journal article
Role of the ER and Golgi in protein export by Apicomplexa
MJ Coffey, C Jennison, CJ Tonkin, JA Boddey
Current Opinion in Cell Biology | Published : 2016
Abstract
Apicomplexan parasites cause diseases of medical and agricultural importance linked to dramatic changes they impart upon infected host cells. Following invasion, the malaria parasite Plasmodium falciparum renovates the host erythrocyte using mechanisms previously believed to be malaria-specific. This involves proteolytic cleavage of effectors in the endoplasmic reticulum that licences proteins for translocation into the host cell. Recently, it was demonstrated that the related parasite Toxoplasma gondii, responsible for disease in immunocompromised individuals and congenital birth defects, has an analogous pathway with some differences, including proteolytic processing in the Golgi. Here we ..
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Awarded by State Government of Victoria
Funding Acknowledgements
We thank Danushka Marapana for critical reading of this manuscript. This work was supported by National Health & Medical Research Council Project Grants 1047806 (CJT), 1010326 and 1049811 (JAB), Human Frontiers Science Program Grant RGY0073/2012 (JAB) and a Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIISS. CJT is an Australian Research Council Future Fellow and JAB is an Australian Research Council Queen Elizabeth II Fellow. The authors declare no competing financial interests. We apologize to authors whose work could not be cited due to space constraints.